14-P015 The bHLH transcription factor NeuroD1 is a differentiation factor during the postnatal olfactory bulb neurogenesis

lysed Wnt signalling activity (target gene expression, transgenic reporter line) following Hedgehog pathway pharmacological interference, or vice versa, and (iii) investigated retinal cell proliferation and determination phenotypes following simultaneous inhibition or activation of the two pathways. Altogether, our data suggest that Wnt and Hedgehog morphogens form opposite gradients within retinal stem cell niche and that these signalling pathways antagonize with each other to control retinal stem cell proliferation and multipotence. Interestingly, our retinal gradient model is reminiscent to the neural tube patterning model.